Join Hannibal Regional Healthcare System Learn more about Hannibal Regional from Todd Ahrens, President and CEO of Hannibal Regional Hannibal Regional Healthcare System - Regional Transportation Hannibal is located along the Mississippi River in northeast Missouri, approximately 100 miles north of St. Louis. The community is intersected by Highway 61 (Avenue of the Saints) and Highway 36 (Chicago to Kansas City Expressway). Hannibal provides convenient, four-lane highway access to St. Louis, Kansas City, Chicago, Memphis, Des Moines, and Minneapolis. Quincy Regional Airport Connect to the world with fast, affordable daily round trip jet service to Chicago. Enjoy convenient baggage check-thru, free parking, and arrive in Chicago in about an hour! Quincy Amtrak Offers daily trips from Quincy to Chicago. Lambert Field - St. Louis, Missouri Located 11 miles northwest of downtown St. Louis along I-70 between I-70 and I-270 in St. Louis County. Medical Campus Photos of Hannibal Regional Medical Campus